J. Technology and Education, Vol.20, No.1, pp.13-19 (2013)

研究論文

フィトステロールおよびミソのマウス血中脂質上昇抑制作用

 

芳野 恭士*¹、後藤 はるな¹、栢村 秀範²

¹沼津工業高等専門学校　物質工学科（〒410-8501　沼津市大岡3600）

²マルコメ株式会社（〒380-0943　長野市安茂里883）

*k-yoshino@numazu-ct.ac.jp

 

Inhibitory Effects of Phytosterols and Soybean Paste on the Elevation

of Lipid Levels in Mouse Plasma

 

Kyoji YOSHINO, Haruna GOTO, Hidenori KAYAMURA

¹Numazu College of Technology (3600 Ooka, Numazu, Shizuoka 410-8501, Japan)

² Marukome Co., Ltd. (883 Amori, Nagano, Nagano 380-0943, Japan)

 

(Received January 17, 2013; Accepted February 19, 2013)

 

Abstract

Metabolic syndrome is known as an important risk factor for cardiovascular disease. Hyperlipidemia and visceral fat accumulation could be caused by excessive fat intake. Soybeans contain several components, such as phytosterols (PS), that lower the levels of serum triglycerides (TG) and cholesterol (Cho) and prevent obesity. In addition, soybean paste (miso) is also known to have inhibitory effects on lipid absorption in animals. In this study, the synergistic effects of PS and miso on mouse plasma lipid levels were investigated. Administration of a high-fat diet or lipids increased the levels of TG and total cholesterol (TC) in mouse plasma. The concurrent ingestion of PS and miso significantly prevented the increase of these lipids in mouse plasma. The usage of PS and miso would be expected to suppress lifestyle-related diseases, such as atherosclerosis.

Key words: Plasma cholesterol, Phytosterols, Miso, Mouse